Nobel laureate James Watson opens TED2005 with the frank and funny story of how he and his partner, Francis Crick, discovered the structure of DNA. The tale is full of colorful details: How Watson had planned to be an ornithologist until Schroedinger's book What Is Life? transformed him into a geneticist. The painful rejections he suffered along the way, first from Caltech and then from a certain girl. And finally, how the basic DNA model ultimately came together in just a few hours. Watson finishes with one of the topics currently making him tick: the search for genetic bases for major illnesses.
James Watson has led a long, remarkable life, starting at age 12, when he was one of radio's high-IQ Quiz Kids. By age 15, he had enrolled in the University of Chicago, and by 25, working with Francis Crick (and drawing, controversially, on the research of Maurice Wilkins and Rosalind Franklin), he had made the discovery that would eventually win the three men the Nobel Prize.
Watson and Crick's 1953 discovery of DNA's double-helix structure paved the way for the astounding breakthroughs in genetics and medicine that marked the second half of the 20th century. And Watson's classic 1968 memoir of the discovery, The Double Helix, changed the way the public perceives scientists, thanks to its candid account of the personality conflicts on the project.
Since 1968, he's presided over the Cold Spring Harbor Laboratory, first as Director, later as President and now as Chancellor. From 1988 to 1994, he ran the Human Genome Project. His current passion is the quest to identify genetic bases for major illnesses.
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